Publications

36) Nguyen, N.H., Shen, S., Banerjee, A., Guerriero, C.J., Chen, J., Wang, J., Mackie, T.D., Welling, P.A., Kleyman, T.R., Bahar, I., Carlson, A.E., and J.L. Brodsky. 2024. Characterization of hyperactive mutations in the renal potassium channel ROMK uncovers unique effects on channel biogenesis and ion conductance. Molecular Biology of the Cell. 35(9): ar119, 1–1. PMID 39024255

35) Commentary: Miller, J.M., and A.E. Carlson. 2024. Locking the hERG channel into place: Using a photoreactive unnatural amino acid to study voltage-gated channel movement. Biophysical Journal. 123(16):2358-2359. PMID 39033327

34) Nishio, S., C. Emori, B. Wiseman, D. Fahrenkamp, E. Dioguardi, S. Zamora-Caballero, M. Bokhove, L. Han, A. Stsiapanava, B. Algarra, Y. Lu, M. Kodani, R.E. Bainbridge, K.M. Komondor, A.E. Carlson, M. Landreh, D. de Sanctis, S. Yasamasu, M. Ikawa, L. Jovine. 2024. ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat. Cell 187 (6): 1440-59. PMID 38490181

33) Rosenbaum, J.C., and A.E. Carlson. 2024. The SARS coronavirus accessory protein ORF3a rescues potassium conductance in yeast. micropublication Biology PMID 38525126 https://doi.org/10.17912/micropub.biology.001129

32) Bainbridge, R.E., J.C. Rosenbaum (co-first author), P. Sau, and A.E. Carlson. Xenopus laevis lack the critical sperm factor PLCζ. [Pre-print] bioRxiv ID: 2023.02.02.526858

31) Rosenbaum, J.C., and A.E. Carlson. Studying metal-protein interactions using fluorescent protein indicators. [Pre-print] bioRxiv ID: 2022.10.13.512174

30) Phelps, W.A., M.D. Hurton, T.N. Ayers, A.E. Carlson, J.C. Rosenbaum, and M.T. Lee. 2023. Hybridization led to a rewired pluripotency network in the allotetraploid Xenopus laevis. eLife: e83952 PMID 37787392 bioRxiv ID: 2022.09.14.507817

29) Komondor, K.M., R.E. Bainbridge (co-first author), K.G. Sharp, J.C. Rosenbaum, and A.E. Carlson. 2023. TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs. Journal of General Physiology. 155(10): e202213258 PMID 37561060

*Research news article highlighting the above article: Short, B. 2023. The fast block to polyspermy breaks with convention. Journal of General Physiology. 155 (10): e202313478. PMID: 37702770

28) Tembo, M., C. Lara-Santos (co-first author), J.C. Rosenbaum, and A.E. Carlson. PIP2 and Ca2+ regulation of TMEM16A currents in excised inside-out patches [Pre-print] bioRxiv ID: 2022.08.30.505925

27) Tembo, M., R.E. Bainbridge, C. Lara-Santos, K.M. Komondor, G.J. Daskivich, J.D. Durrant, J.C. Rosenbaum, and A.E. Carlson. 2022. Phosphate position is key in mediating the transmembrane ion channel TMEM16A-phosphatidylinositol 4, 5-bisphosphate interaction. Journal of Biological Chemistry. 298(8): 102264 PMID 35843309

26) Tembo, M., M.L. Sauer, B.W. Wisner, D.O. Beleny, M.A. Napolitano, and A.E. Carlson. 2021. Actin polymerization is not required for the fast block to polyspermy in the African clawed frog, Xenopus laevis. microPublication Biology 10.17912/micropub.biology.000365. PMID 33598639

25) Phelps, W.A., A.E. Carlson, and M.T. Lee. 2021. Optimized design of antisense oligomers for targeted rRNA depletion. Nucleic Acids Research. PMID 33221877

24) Commentary: Komondor, K.M., and A.E. Carlson. 2020. Sperm: Secrets of Success. eLife 9:e64379. PMID 33263540 Manuscript

23) Wozniak, K.L, R.E. Bainbridge (co-first author), D.W. Summerville, M. Tembo, W.A. Phelps, M.L. Sauer, B.W. Wisner, M.E. Czekalski, S. Pasumarthy, M.L. Hanson, M.B. Linderman, C.H. Luu, M.E. Boehm, S.M. Sanders, K.M. Buckley, D.J. Bain, M.L. Nicotra, M.T. Lee, and A.E. Carlson. 2020. Zinc protection of fertilized eggs is an ancient feature of sexual reproduction in animals. PLOS Biology. 18(7): e3000811 PMID32735558

22) Review: Wozniak, K.L., and A.E. Carlson. 2020. Ion channels and signaling pathways used in the fast polyspermy block. Molecular Reproduction and Development. 87 (3): 350-7. PMID31087507

21) Commentary: Carlson A.E. 2019. Mechanical stimulation activates Drosophila eggs via Trpm channels. Proceedings of the National Academy of Sciences. 116 (38): 18757-8. PMID31455728

20) Commentary: Bainbridge, R.E., and A.E. Carlson. 2019. Tiny dancer: EFCAB9 triggers hyperactivation via CatSper. Trends in Biochemical Sciences. 44 (10): 823-6. PMID31447243

19) Tembo, M., Wozniak, K.L., Bainbridge, R.E., and A.E. Carlson. 2019. Phosphatidylinositol 4,5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl- channel TMEM16A. Journal of Biological Chemistry. 294 (33): 12556-64. PMID31266809

18) Commentary: Tembo, M. and A.E. Carlson. 2019. Under pressure: Ano1 mediates pressure sensing in the lymphatic system. Journal of General Physiology. 151 (4): 404-6. PMID30886053

17) Wozniak, K.L., M. Tembo, W.A. Phelps, M.T. Lee, and A.E. Carlson. 2018. PLC and IP3-evoked Ca2+ release initiate the fast block to polyspermy in Xenopus laevis. Journal of General Physiology. 150 (9): 1239-48. PMID30012841

16) Wozniak, K.L., W.A. Phelps, M. Tembo, M.T. Lee, and A.E. Carlson. 2018. The TMEM16A channel mediates the fast polyspermy block in Xenopus laevis. Journal of General Physiology. 150 (9): 1249-59. PMID30012842 bioRxiv Preprint

      *Anne was awarded the 2018 Paul F. Cranefield Award from the Society of General Physiologists for the above two manuscripts.

      *Commentary highlighting above two articles: Jaffe, L.A. 2018. The fast block to polyspermy: New insights into a century-old problem. Journal of General Physiology. 150 (9): 1233-4. PMID30082432

       *Above two articles featured by cover image

15) Wozniak, K.L., B.L. Mayfield (co-first author), M. Tembo, D.O. Beleny, M.A. Napolitano, M.L. Sauer, B.W. Wisner, and A.E. Carlson. 2017. Extracellular Ca2+ is required for fertilization in the African clawed frog, Xenopus laevis. PLoS One 12 (1): e0170405. PMID28114360

A.E. Carlson publications before 2014 appointment at the University of Pittsburgh

14) Carlson, A.E., J.C. Rosenbaum, T.I Brelidze, R.E. Klevit, and W.N. Zagotta. 2013. Fisetin potentiates HCN2 channels. Journal of Biological Chemistry 288: 33136-45.  PMC3831264

13) Haitin, Y., A.E. Carlson, and W.N. Zagotta. 2013. Structural mechanism for regulation of KCNH channels by the EAG domain. Nature 501: 444-8. PMC3910112

12) Carlson, A.E., T.I Brelidze, and W.N. Zagotta. 2013. Flavonoid Regulation of EAG1 channels. Journal of General Physiology 141: 347-58. PMC3581696 

11) Brelidze, T.I., A.E. Carlson, B. Sankarian, and W.N. Zagotta. 2012. Structure of the carboxy-terminal region of a KCNH Channel. Nature 481: 530-3. PMC3267858 

10) Carlson, A.E., T.I. Brelidze (co-first author), D.R. Davies, L J. Stewart, and W.N. Zagotta. 2010. Identifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen. PLoS One 5 (9): e12523. PMC2932742

9) Carlson, A.E., L.A. Burnett, D. del Camino, T.A. Quill, B. Hille, J.A. Chong, M.M. Moran, D.F. Babcock. 2009. Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One 4 (e6844): 1-9. PMC2729922

8) Brelidze, T.I., A.E. Carlson, W.N. Zagotta. 2009. Absence of a direct cyclic nucleotide modulation of mEAG and hERG1 channels revealed with fluorescence and electrophysiological methods. Journal of Biological Chemistry 284: 27989-97. PMC2788851

7) Carlson, A.E., B. Hille, D.F. Babcock. 2007. External Ca2+ acts upstream of adenylyl cyclase SACY in the bicarbonate signaled activation of sperm motility. Developmental Biology 312: 183-92. PMC2259292

6) Xie, F., M.A. Garcia, A.E. Carlson, S.M. Schuh, B.S. Jaiswal, M. van Duin, D.F. Babcock, and M. Conti. 2006. Soluble adenylyl cyclase is indispensable for sperm function and fertilization. Developmental Biology 296: 353-362. PMID16842770

5) Schuh, S.M., A.E. Carlson, G.S. McKnight, M. Conti, B. Hille, D.F. Babcock. 2006. Signaling pathways for modulation of mouse sperm motility by adenosine and catecholamine agonists. Biology of Reproduction 74: 492-500. PMID16291925

4) Carlson, A.E., T. Quill, R.E. Westenbroek, S.M. Schuh, B. Hille, and D.F. Babcock. 2005. Identical phenotypes of CatSper1 and CatSper2 null sperm. Journal of Biological Chemistry 280: 32238-44. PMID16036917

3) Carlson, A.E., R.E. Westenbroek, T. Quill, D. Ren, D.E. Clapham, B. Hille, D.L. Garbers, and D.F. Babcock. 2003. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proceedings of the National Academy of Science 100: 14864-8. PMC299831 

2) Wennemuth, G., A.E. Carlson, A.J. Harper, and D.F. Babcock. 2003. Bicarbonate actions on flagellar and Ca2+ -channel responses: Initial events in sperm activation. Development 130: 1317-26. PMID12588848

1) Rosenbaum, T., L.D. Islas, A.E. Carlson, and S.E. Gordon. 2003. Dequalinium: A novel, high-affinity blocker of CNGA1 channels. Journal of General Physiology 121: 37-47. PMC2217319